Chinese Medicine Formula Siwu-Yin Inhibits Esophageal Precancerous Lesions by Improving Intestinal Flora and Macrophage Polarization
Siwu-Yin (SWY), a traditional Chinese medicinal formula, can replenish blood and nourish Yin. It was recorded in ancient Chinese medicine books in treating esophageal dysphagia, which has similar symptoms and prognosis with esophageal precancerous lesions and esophageal cancer. However, its effect h...
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Frontiers Media S.A.,
2022-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_e661744cf0c44d889c20cf88f0e76cec | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Hui-Juan Shi |e author |
| 700 | 1 | 0 | |a Xuan-Yu Chen |e author |
| 700 | 1 | 0 | |a Xin-Ran Chen |e author |
| 700 | 1 | 0 | |a Zhong-Bing Wu |e author |
| 700 | 1 | 0 | |a Jian-Yong Li |e author |
| 700 | 1 | 0 | |a Ya-Qin Sun |e author |
| 700 | 1 | 0 | |a Dong-Xuan Shi |e author |
| 700 | 1 | 0 | |a Jing Li |e author |
| 700 | 1 | 0 | |a Jing Li |e author |
| 245 | 0 | 0 | |a Chinese Medicine Formula Siwu-Yin Inhibits Esophageal Precancerous Lesions by Improving Intestinal Flora and Macrophage Polarization |
| 260 | |b Frontiers Media S.A., |c 2022-03-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.812386 | ||
| 520 | |a Siwu-Yin (SWY), a traditional Chinese medicinal formula, can replenish blood and nourish Yin. It was recorded in ancient Chinese medicine books in treating esophageal dysphagia, which has similar symptoms and prognosis with esophageal precancerous lesions and esophageal cancer. However, its effect has not been established in vivo. This study explores the antiesophageal cancer effect of SWY on rats with esophageal precancerous lesions. By performing 16S rRNA gene sequencing and metabolomics, it was suggested that SWY may improve the composition of intestinal flora of rats by regulating the synthesis and secretion of bile acids. In addition, flow cytometry results showed that SWY treatment modified tumor microenvironment by improving macrophage polarization and therefore inhibiting the occurrence of esophageal precancerous lesions. | ||
| 546 | |a EN | ||
| 690 | |a esophageal precancerous lesions | ||
| 690 | |a Siwu-Yin | ||
| 690 | |a synthesis and secretion of bile acids | ||
| 690 | |a macrophage polarization | ||
| 690 | |a metabolomics | ||
| 690 | |a traditional Chinese medicine | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.812386/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e661744cf0c44d889c20cf88f0e76cec |z Connect to this object online. |