Cover Image

PPAR-γ Activation Exerts an Anti-inflammatory Effect by Suppressing the NLRP3 Inflammasome in Spinal Cord-Derived Neurons

Persistent inflammation disrupts functional recovery after spinal cord injury (SCI). Peroxisome proliferator-activated receptor gamma (PPAR-γ) activation promotes functional recovery in SCI rats by inhibiting inflammatory cascades and increasing neuronal survival. We sought to clarify the relationsh...

Full description

Saved in:

Bibliographic Details
Main Authors:	Qing-Qi Meng (Author), Zhen-Cheng Feng (Author), Xing-Liang Zhang (Author), Li-Qiong Hu (Author), Min Wang (Author), Hai-Feng Zhang (Author), Si-Ming Li (Author)
Format:	Book
Published:	Hindawi Limited, 2019-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Entinostat Improves Motor Function and Neuronal Damage Via Downregulating NLRP3 Inflammasome Activation After Spinal Cord Injury
by: Chen Dai, et al.
Published: (2021)

Amentoflavone Affects Epileptogenesis and Exerts Neuroprotective Effects by Inhibiting NLRP3 Inflammasome
by: Shikuo Rong, et al.
Published: (2019)

Pioglitazone, a PPAR-γ Activator, Stimulates BKCa but Suppresses IKM in Hippocampal Neurons
by: Tsang-Shan Chen, et al.
Published: (2018)

Heat‐killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome
by: Hong‐Xia Fan, et al.
Published: (2023)

Sulfonylureas exert antidiabetic action on adipocytes by inhibition of PPARγ serine 273 phosphorylation
by: Bodo Haas, et al.
Published: (2024)

PPARγ in Ischemia-Reperfusion Injury: Overview of the Biology and Therapy
by: Ruizhen Huang, et al.
Published: (2021)

Huazhuotongmai decoction exerts anti-atherosclerotic effects by modulating the expression of ABCA1/SR-B1/PPAR-γ in vivo and in vitro
by: Ya-ru Yan, et al.
Published: (2023)

Icariside II Exerts Anti-Type 2 Diabetic Effect by Targeting PPARα/γ: Involvement of ROS/NF-κB/IRS1 Signaling Pathway
by: Yiqi Li, et al.
Published: (2022)

Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator
by: Xinni Xie, et al.
Published: (2017)

Teuvincenone F Suppresses LPS-Induced Inflammation and NLRP3 Inflammasome Activation by Attenuating NEMO Ubiquitination
by: Xibao Zhao, et al.
Published: (2017)

Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC
by: Jia Zhao, et al.
Published: (2023)

Lycopus lucidus Turcz Exerts Neuroprotective Effects Against H2O2-Induced Neuroinflammation by Inhibiting NLRP3 Inflammasome Activation in Cortical Neurons
by: Kim H, et al.
Published: (2021)

Itaconate Suppresses the Activation of Mitochondrial NLRP3 Inflammasome and Oxidative Stress in Allergic Airway Inflammation
by: Qiu-Meng Xie, et al.
Published: (2023)

Evodiamine Augments NLRP3 Inflammasome Activation and Anti-bacterial Responses Through Inducing α-Tubulin Acetylation
by: Chen-Guang Li, et al.
Published: (2019)

Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy
by: Jingxue Ye, et al.
Published: (2020)

Total flavonoids of hawthorn leaves protect spinal motor neurons via promotion of autophagy after spinal cord injury
by: Qiong Zhang, et al.
Published: (2022)

Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway
by: Xiao Liu, et al.
Published: (2019)

Sinapine Thiocyanate Ameliorates Vascular Endothelial Dysfunction in Hypertension by Inhibiting Activation of the NLRP3 Inflammasome
by: Yang Liu, et al.
Published: (2021)

Scutellarin Suppresses NLRP3 Inflammasome Activation in Macrophages and Protects Mice against Bacterial Sepsis
by: Yi Liu, et al.
Published: (2018)

A glimpse of the connection between PPARγ and macrophage
by: Lexiang Yu, et al.
Published: (2023)

Preclinical Investigation of Alpinetin in the Treatment of Cancer-Induced Cachexia via Activating PPARγ
by: Yujie Zhang, et al.
Published: (2021)

Yanghe Decoction Suppresses the Experimental Autoimmune Thyroiditis in Rats by Improving NLRP3 Inflammasome and Immune Dysregulation
by: Bing'e Ma, et al.
Published: (2021)

Myrtenal and β-caryophyllene oxide screened from Liquidambaris Fructus suppress NLRP3 inflammasome components in rheumatoid arthritis
by: Wen-xuan Li, et al.
Published: (2021)

PPAR γ agonist, pioglitazone, suppresses melanoma cancer in mice by inhibiting TLR4 signaling
by: Nasim Dana, et al.
Published: (2019)

Polyphyllin I exerts anti-hepatocellular carcinoma activity by targeting ZBTB16 to activate the PPARγ/RXRα signaling pathway
by: Lu shan, et al.
Published: (2024)

Zerumbone Suppresses the LPS-Induced Inflammatory Response and Represses Activation of the NLRP3 Inflammasome in Macrophages
by: Chia-Cheng Su, et al.
Published: (2021)

Corrigendum: Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy
by: Jingxue Ye, et al.
Published: (2021)

The Role of NLRP3 Inflammasome Signaling on Arrhythmias in Diabetes
by: Zhang L, et al.
Published: (2022)

The role of NLRP3 inflammasome in hepatocellular carcinoma
by: Huijie Zhao, et al.
Published: (2023)

MicroRNA-223 Suppresses IL-1β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome
by: Quan-Bo Zhang, et al.
Published: (2021)

Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR
by: Bin Leng, et al.
Published: (2019)

Tanreqing injection inhibits dengue virus encephalitis by suppressing the activation of NLRP3 inflammasome
by: Hefei Huang, et al.
Published: (2024)

Angiotensin II-induced muscle atrophy via PPARγ suppression is mediated by miR-29b
by: Jin Li, et al.
Published: (2021)

Astragaloside IV attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation
by: Xianhong Li, et al.
Published: (2024)

Activation of the PPARγ Prevents Ferroptosis-Induced Neuronal Loss in Response to Intracerebral Hemorrhage Through Synergistic Actions With the Nrf2
by: Chenyang Duan, et al.
Published: (2022)

Ups and downs: The PPARγ/p-PPARγ seesaw of follistatin-like 1 and integrin receptor signaling in adipogenesis
by: Dongliang Fang, et al.
Published: (2022)

Kuhuang injection exerts a protective effect by activating PPAR-γ in an in vitro model of chlorpromazine-induced cholestatic liver injury constructed by tissue engineering
by: Qiao Wu, et al.
Published: (2022)

Novel phenyl-urea derivatives as dual-target ligands that can activate both GK and PPARγ
by: Lijian Zhang, et al.
Published: (2012)

SIRT1 Alleviates Aldosterone-Induced Podocyte Injury by Suppressing Mitochondrial Dysfunction and NLRP3 Inflammasome Activation
by: Mingzhu Jiang, et al.
Published: (2021)

Agnuside Alleviates Synovitis and Fibrosis in Knee Osteoarthritis through the Inhibition of HIF-1α and NLRP3 Inflammasome
by: Li Zhang, et al.
Published: (2021)