Protective Effect of γ-Irradiation Against Hypochlorous Acid-Induced Haemolysis in Human Erythrocytes
Radiations may trigger protective response within a threshold of doses applied. Exposures above an upper threshold are generally detrimental, while exposures below a lower threshold may or may not increase risks for health. We recently reported that a cellular protective response occurs in intervent...
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| Main Authors: | , , , , , |
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| Format: | Book |
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SAGE Publishing,
2013-07-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_e6b1302d25a34dc39529f0444df48d2f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Idolo Tedesco |e author |
| 700 | 1 | 0 | |a Carmela Spagnuolo |e author |
| 700 | 1 | 0 | |a Maria Russo |e author |
| 700 | 1 | 0 | |a Roberta Iannitti |e author |
| 700 | 1 | 0 | |a Annunziata Nappo |e author |
| 700 | 1 | 0 | |a Gian Luigi Russo |e author |
| 245 | 0 | 0 | |a Protective Effect of γ-Irradiation Against Hypochlorous Acid-Induced Haemolysis in Human Erythrocytes |
| 260 | |b SAGE Publishing, |c 2013-07-01T00:00:00Z. | ||
| 500 | |a 1559-3258 | ||
| 500 | |a 10.2203/dose-response.12-025.Tedesco | ||
| 520 | |a Radiations may trigger protective response within a threshold of doses applied. Exposures above an upper threshold are generally detrimental, while exposures below a lower threshold may or may not increase risks for health. We recently reported that a cellular protective response occurs in interventional cardiologists to counteract the oxidative damage caused by radiation. Here, we demonstrated in an in vitro model represented by whole blood of healthy donors γ-irradiated with 220-440 mGy, that haemolysis of erythrocytes induced by hypochlorous acid was reduced by 40%. The protection triggered by γ-radiations made erythrocytes more resistant to oxidative insult caused by hypochlorous acid which was induced 3 h after irradiation and involved biochemical changes in the synthesis and turnover of glutathione. Overall, the biochemical remodelling induced by exposure to γ-radiations might contribute to generate new guidelines in professionally exposed workers. | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Dose-Response, Vol 11 (2013) | |
| 787 | 0 | |n https://doi.org/10.2203/dose-response.12-025.Tedesco | |
| 787 | 0 | |n https://doaj.org/toc/1559-3258 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e6b1302d25a34dc39529f0444df48d2f |z Connect to this object online. |