Saponins from the roots of Chenopodium bonus-henricus L. with neuroprotective and anti-α-glucosidase activities
Six saponins of phytolaccagenin, bayogenin, medicagenic acid, 2β-hydroxygypsogenin, and 2β-hydroxyoleanoic acid from the roots of Chenopodium bonus-henricus L. were investigated for neuroprotective and anti-α-glucosidase activities. All tested saponins (10 µM) showed statistically significant neurop...
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Pensoft Publishers,
2021-04-01T00:00:00Z.
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| 001 | doaj_e6e84a3ea8cc4581a3a6fe2c6a45644d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Zlatina Kokanova-Nedialkova |e author |
| 700 | 1 | 0 | |a Magdalena Kondeva-Burdina |e author |
| 700 | 1 | 0 | |a Paraskev Nedialkov |e author |
| 245 | 0 | 0 | |a Saponins from the roots of Chenopodium bonus-henricus L. with neuroprotective and anti-α-glucosidase activities |
| 260 | |b Pensoft Publishers, |c 2021-04-01T00:00:00Z. | ||
| 500 | |a 10.3897/pharmacia.68.e64425 | ||
| 500 | |a 2603-557X | ||
| 520 | |a Six saponins of phytolaccagenin, bayogenin, medicagenic acid, 2β-hydroxygypsogenin, and 2β-hydroxyoleanoic acid from the roots of Chenopodium bonus-henricus L. were investigated for neuroprotective and anti-α-glucosidase activities. All tested saponins (10 µM) showed statistically significant neuroprotective activities on isolated rat brain synaptosomes using a 6-hydroxydopamine in vitro model. They preserved synaptosome viability as well as the reduced glutathione level. The bayogenin glycoside (Chbhs-05) possessed the most prominent neuroprotective effect. The anti-α-glucosidase activity of the tested saponins was established by measuring the levels of the released 4-nitrophenol using LC-MS. Bonushenricoside B (Chbhs-07) showed the highest inhibitory effect against α-glucosidase (44.1%) compared to the positive control acarbose (36.3%) at a concentration of 625 µM. | ||
| 546 | |a EN | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmacia, Vol 68, Iss 2, Pp 387-392 (2021) | |
| 787 | 0 | |n https://pharmacia.pensoft.net/article/64425/download/pdf/ | |
| 787 | 0 | |n https://pharmacia.pensoft.net/article/64425/download/xml/ | |
| 787 | 0 | |n https://pharmacia.pensoft.net/article/64425/ | |
| 787 | 0 | |n https://doaj.org/toc/2603-557X | |
| 856 | 4 | 1 | |u https://doaj.org/article/e6e84a3ea8cc4581a3a6fe2c6a45644d |z Connect to this object online. |