Effect of Sechium edule on chemical induced kidney damage in experimental animals
The aqueous extract of leaves of Sechium edule was evaluated for its protective activity against gentamicin, potassium dichromate-induced nephrotoxicity and streptozotocin-induced diabetic nephropathy in experimental animals. In these three conditions, the extract of S. edule (200 mg/kg) has signifi...
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| Main Authors: | , , |
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| Format: | Book |
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Bangladesh Pharmacological Society,
2012-12-01T00:00:00Z.
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| Summary: | The aqueous extract of leaves of Sechium edule was evaluated for its protective activity against gentamicin, potassium dichromate-induced nephrotoxicity and streptozotocin-induced diabetic nephropathy in experimental animals. In these three conditions, the extract of S. edule (200 mg/kg) has significantly (p<0.001) decreased the level of blood urea, blood urea nitrogen and serum creatinine and also significantly (p<0.001) increased the serum levels of total protein. The serum uric acid level was also significantly (p<0.001) decrease in diabetic mice treated with the extract (200 mg/kg). The extract also improves the histology of the kidney. The results indicate that aqueous extract of leaves of S. edule has possessed protective effect against gentamicin- and potassium dichromate-induced nephrotoxicity and streptozotocin-induced diabetic nephropathy in experimental animals. |
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| Item Description: | 10.3329/bjp.v8i1.12982 1991-0088 |