A case study of a patient‐centered reverse translational systems‐based approach to understand adverse event profiles in drug development

• Main Authors: Sarah Kim (Author), Gezim Lahu (Author), Majid Vakilynejad (Author), Theodoros G. Soldatos (Author), David B. Jackson (Author), Lawrence J. Lesko (Author), Mirjam N. Trame (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Adverse drug reactions (ADRs) of targeted therapy drugs (TTDs) are frequently unexpected and long‐term toxicities detract from exceptional efficacy of new TTDs. In this proof‐of‐concept study, we explored how molecular causation involved in trastuzumab‐induced cardiotoxicity changes when tr...