Uric acid and risk of gestational diabetes mellitus: an observational study and mendelian randomization analysis

Abstract Objective Our aim was to explore the relationship between serum uric acid (UA) levels in early pregnancy and the development of gestational diabetes mellitus (GDM), and to further explore whether there is a causal relationship. Methods 684 pregnant women with GDM and 1162 pregnant women wit...

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Main Authors: Nuerbiya Xilifu (Author), Rui Zhang (Author), Yongling Dai (Author), Miyeshaer Maimaiti (Author), Zhangyan Li (Author), Ju Yang (Author), Shufei Zang (Author), Jun Liu (Author)
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Published: BMC, 2024-08-01T00:00:00Z.
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001 doaj_e73e04c0d76d4fcdbe82fbe0bbd59e1f
042 |a dc 
100 1 0 |a Nuerbiya Xilifu  |e author 
700 1 0 |a Rui Zhang  |e author 
700 1 0 |a Yongling Dai  |e author 
700 1 0 |a Miyeshaer Maimaiti  |e author 
700 1 0 |a Zhangyan Li  |e author 
700 1 0 |a Ju Yang  |e author 
700 1 0 |a Shufei Zang  |e author 
700 1 0 |a Jun Liu  |e author 
245 0 0 |a Uric acid and risk of gestational diabetes mellitus: an observational study and mendelian randomization analysis 
260 |b BMC,   |c 2024-08-01T00:00:00Z. 
500 |a 10.1186/s12958-024-01278-8 
500 |a 1477-7827 
520 |a Abstract Objective Our aim was to explore the relationship between serum uric acid (UA) levels in early pregnancy and the development of gestational diabetes mellitus (GDM), and to further explore whether there is a causal relationship. Methods 684 pregnant women with GDM and 1162 pregnant women without GDM participated in this study. 311 pregnant women with GDM and 311 matched controls were enrolled in a 1:1 case-control study. We used conditional logistic regression to explore the relationship between UA levels and the risk of developing GDM. The causal relationship between the two was examined by two-sample Mendelian randomization (MR) analysis. Results In the 1:1 matched population, the odds ratio (OR) of developing GDM compared with the extreme tertiles of UA levels was 1.967 (95% confidence interval [CI]: 1.475-2.625; P < 0.001). Restricted cubic spline analyses showed a linear relationship between UA and GDM when UA exceeded 222 µmol/L. GDM and UA levels maintained a statistically significant positive correlation in different stratified regression analyses (P < 0.001). However, no evidence of a causal relationship between uric acid and GDM was found by MR analyses with an OR of 1.06 (95% CI: 0.91-1.25) per unit increase in UA. Conclusion There is a positive correlation between UA levels in early pregnancy and the subsequent risk of developing GDM. However, no genetic evidence was found to support a cause-effect relationship between UA and GDM. 
546 |a EN 
690 |a Early pregnancy uric acid (UA) 
690 |a Gestational diabetes mellitus (GDM) 
690 |a Mendelian randomization analysis (MR) 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
690 |a Reproduction 
690 |a QH471-489 
655 7 |a article  |2 local 
786 0 |n Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-8 (2024) 
787 0 |n https://doi.org/10.1186/s12958-024-01278-8 
787 0 |n https://doaj.org/toc/1477-7827 
856 4 1 |u https://doaj.org/article/e73e04c0d76d4fcdbe82fbe0bbd59e1f  |z Connect to this object online.