An unexpected fever post serogroup B meningococcal sepsis

• Main Authors: Daniele Donà (Author), Elisa Gnoato (Author), Carlo Giaquinto (Author), Carlo Moretti (Author)
• Format: Book
• Published: MDPI AG, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2036-749X; 2036-7503; 10.4081/pr.2016.6613
• Keywords: Neisseria meningitidis serogroup B; Kawasaki Diseases; Corticosteroid therapy macrophage activation syndrome; Medicine; R; Pediatrics; RJ1-570
• Source: Pediatric Reports, Vol 8, Iss 4 (2016)

This case report describes an invasive meningococcal group B infection followed by the development of Kawasaki disease (KD) complicated by macrophage activation syndrome (MAS) in a 2-year-old child. The presented case indicates the possible etiologic relationship between meningococcal sepsis and KD as support of bacterial toxin induced theory. It's important to maintain a high grade of suspicious for KD in every relapse of fever also during convalescence phase of severe infection. Usually, initial treatment with intravenous immunoglobulin is sufficient to control the disease; but, in case of refractory KD complicated by MAS, corticosteroid therapy represents a good option inducing prompt fever resolution and clinical improvement.