C/EBPβ-LIP mediated activation of the malate-aspartate shuttle sensitizes cells to glycolysis inhibition

• Main Authors: Tobias Ackermann (Author), Hidde R. Zuidhof (Author), Christine Müller (Author), Gertrud Kortman (Author), Martijn G.S. Rutten (Author), Mathilde J.C. Broekhuis (Author), Mohamad Amr Zaini (Author), Götz Hartleben (Author), Cornelis F. Calkhoven (Author)
• Formato: Libro
• Publicado: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Objective: Cancer cells use glycolysis for generation of metabolic intermediates and ATP needed for cell growth and proliferation. The transcription factor C/EBPβ-LIP stimulates glycolysis and mitochondrial respiration in cancer cells. We initially observed that high expression of C/EBPβ-LIP makes c...