Cover Image

Total Extracts of Abelmoschus manihot L. Attenuates Adriamycin-Induced Renal Tubule Injury via Suppression of ROS-ERK1/2-Mediated NLRP3 Inflammasome Activation

Abelmoschus manihot (L.) Medik. (Malvaceae) is a herb used in traditional Chinese medicine to treat some kidney diseases. To date, the detailed mechanisms by which A. manihot improves some kinds of renal disease are not fully understood. In this study, we established Adriamycin-induced NRK-52E cells...

Full description

Saved in:

Bibliographic Details
Main Authors:	Wei Li (Author), Weiming He (Author), Ping Xia (Author), Wei Sun (Author), Ming Shi (Author), Yao Zhou (Author), Weiwei Zhu (Author), Lu Zhang (Author), Buhui Liu (Author), Jingjing Zhu (Author), Yiye Zhu (Author), Enchao Zhou (Author), Minjie Sun (Author), Kun Gao (Author)
Format:	Book
Published:	Frontiers Media S.A., 2019-05-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Total extract of Abelmoschus manihot L. alleviates uric acid-induced renal tubular epithelial injury via inhibition of caspase-8/caspase-3/NLRP3/GSDME signaling
by: Zhihui Ding, et al.
Published: (2022)

Evaluation of the efficacy of Abelmoschus manihot (L.) on diabetic nephropathy by analyzing biomarkers in the glomeruli and proximal and distal convoluted tubules of the kidneys
by: Hongmei Yu, et al.
Published: (2023)

Chalcone Derivatives From Abelmoschus manihot Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization
by: Jinsong Su, et al.
Published: (2022)

Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy
by: Zhipeng Diao, et al.
Published: (2024)

Exploring the total flavones of Abelmoschus manihot against IAV-induced lung inflammation by network pharmacology
by: Yanan Gao, et al.
Published: (2022)

Total Flavone of Abelmoschus manihot Ameliorates TNBS-Induced Colonic Fibrosis by Regulating Th17/Treg Balance and Reducing Extracellular Matrix
by: Lichao Qiao, et al.
Published: (2021)

Effects of Abelmoschus manihot (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut-kidney axis
by: Hongmei Yu, et al.
Published: (2024)

Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling
by: Bu-Hui Liu, et al.
Published: (2021)

Efficacy and safety of Abelmoschus manihot capsule combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta analysis
by: Ying Tan, et al.
Published: (2024)

Total Flavones of Abelmoschus manihot Remodels Gut Microbiota and Inhibits Microinflammation in Chronic Renal Failure Progression by Targeting Autophagy-Mediated Macrophage Polarization
by: Yue Tu, et al.
Published: (2020)

Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance
by: Yumeng Wang, et al.
Published: (2024)

Saikosaponin d Alleviates Liver Fibrosis by Negatively Regulating the ROS/NLRP3 Inflammasome Through Activating the ERβ Pathway
by: Kehui Zhang, et al.
Published: (2022)

Traditional Uses, Chemical Constituents, Biological Properties, Clinical Settings, and Toxicities of Abelmoschus manihot L.: A Comprehensive Review
by: Fei Luan, et al.
Published: (2020)

Total Flavone of Abelmoschus manihot Ameliorates Stress-Induced Microbial Alterations Drive Intestinal Barrier Injury in DSS Colitis
by: Wang R, et al.
Published: (2021)

Integrated Network Pharmacology Analysis and Pharmacological Evaluation to Explore the Active Components and Mechanism of Abelmoschus manihot (L.) Medik. on Renal Fibrosis
by: Gu L, et al.
Published: (2020)

Total flavones of Abelmoschus manihot improve diabetic nephropathy by inhibiting the iRhom2/TACE signalling pathway activity in rats
by: Su Liu, et al.
Published: (2018)

Integrated analysis of comprehensive metabolomics and network pharmacology to reveal the mechanisms of abelmoschus manihot (L.) medik. in the treatment of cisplatin-induced chronic kidney disease
by: Jian-Cheng Liao, et al.
Published: (2022)

Electroacupuncture improves gout arthritis pain via attenuating ROS-mediated NLRP3 inflammasome overactivation
by: Huina Wei, et al.
Published: (2023)

Lisinopril Protects Against the Adriamycin Nephropathy and Reverses the Renalase Reduction: Potential Role of Renalase in Adriamycin Nephropathy
by: Pengxun Han, et al.
Published: (2013)

Norcantharidin ameliorates estrogen deficient-mediated bone loss by attenuating the activation of extracellular signal-regulated kinase/ROS/NLRP3 inflammasome signaling
by: Guang Yang, et al.
Published: (2022)

ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury
by: Shichao Han, et al.
Published: (2015)

Apoptosis and remodeling in adriamycin-induced cardiomyopathy rat model
by: Young Mi Hong, et al.
Published: (2017)

Astragaloside IV attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation
by: Xianhong Li, et al.
Published: (2024)

Keep the corners; adriamycin nephropathy
by: Mahnaz Momenzadeh
Published: (2023)

PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection.
by: Marina Tiemi Shio, et al.
Published: (2015)

Korean Chestnut Honey Suppresses HSV-1 Infection by Regulating the ROS-NLRP3 Inflammasome Pathway
by: Eun-Bin Kwon, et al.
Published: (2023)

Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production
by: Ilandarage Menu Neelaka Molagoda, et al.
Published: (2021)

Maternal High-Fat Diet Programs Renal Peroxisomes and Activates NLRP3 Inflammasome-Mediated Pyroptosis in the Rat Fetus
by: Zhou P, et al.
Published: (2021)

Indole-3-Carboxaldehyde Alleviates LPS-Induced Intestinal Inflammation by Inhibiting ROS Production and NLRP3 Inflammasome Activation
by: Ji Cao, et al.
Published: (2024)

RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose
by: Chenlin Gao, et al.
Published: (2019)

Gallic acid ameliorates dextran sulfate sodium-induced ulcerative colitis in mice via inhibiting NLRP3 inflammasome
by: Tian-Yuan Yu, et al.
Published: (2023)

Platelet-rich plasma inhibits Adriamycin-induced inflammation via blocking the NF-κB pathway in articular chondrocytes
by: Haijun Zhao, et al.
Published: (2021)

Dapagliflozin Does Not Protect against Adriamycin-Induced Kidney Injury in Mice
by: Jin Joo Cha, et al.
Published: (2024)

Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
by: Zhi-Qiang Ouyang, et al.
Published: (2023)

Calycosin Alleviates Sepsis-Induced Acute Lung Injury via the Inhibition of Mitochondrial ROS-Mediated Inflammasome Activation
by: Yu Xia, et al.
Published: (2021)

Global trends and prospects about inflammasomes in stroke: a bibliometric analysis
by: Junjun Yin, et al.
Published: (2021)

The Anti-Glioma Effect of Juglone Derivatives through ROS Generation
by: Jinsen Zhang, et al.
Published: (2022)

PGK1 facilities cisplatin chemoresistance by triggering HSP90/ERK pathway mediated DNA repair and methylation in endometrial endometrioid adenocarcinoma
by: Jing-Wei Zhou, et al.
Published: (2019)

The role of NLRP3 inflammasome in the pathogenesis of rheumatic disease
by: Ruixue Kong, et al.
Published: (2022)

Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes
by: Fan W, et al.
Published: (2021)