The Anti-Glioma Effect of Juglone Derivatives through ROS Generation

• Main Authors: Jinsen Zhang (Author), Minjie Fu (Author), Jinfeng Wu (Author), Fengfeng Fan (Author), Xin Zhang (Author), Chunjie Li (Author), Hui Yang (Author), Yonghe Wu (Author), Yiming Yin (Author), Wei Hua (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Juglone has been extensively reported as a natural antitumor pigment. However, it is easy to be oxidized due to active hydroxy in the quinone. Here, we designed some new juglone derivatives, as the hydroxy was replaced by methyl (D1), allyl (D2), butyl (D3), and benzyl (D4) groups. Nuclear magnetic...