Combining Therapeutic Drug Monitoring and Pharmacokinetic Modelling Deconvolutes Physiological and Environmental Sources of Variability in Clozapine Exposure

• Main Authors: Kenneth H. Wills (Author), Stephen J. Behan (Author), Michael J. Nance (Author), Jessica L. Dawson (Author), Thomas M. Polasek (Author), Ashley M. Hopkins (Author), Madelé van Dyk (Author), Andrew Rowland (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background:</b> Clozapine is a key antipsychotic drug for treatment-resistant schizophrenia but exhibits highly variable pharmacokinetics and a propensity for serious adverse effects. Currently, these challenges are addressed using therapeutic drug monitoring (TDM). This study primari...