Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice

• Main Authors: Fleur Schaper (Author), Mirjan M van Timmeren (Author), Arjen Petersen (Author), Gerda Horst (Author), Marc Bijl (Author), Pieter C Limburg (Author), Johanna Westra (Author), Peter Heeringa (Author)
• Format: Book
• Published: BMC, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract High mobility group box 1 (HMGB1) is a nuclear DNA binding protein that acts as an alarmin when secreted. HMGB1 is increased in systemic lupus erythematosus and might represent a potential therapeutic target. We investigated whether treatment with an anti-HMGB1 antibody affects the developm...