Bufotalin Induces Oxidative Stress-Mediated Apoptosis by Blocking the ITGB4/FAK/ERK Pathway in Glioblastoma

• Main Authors: Junchao Tan (Author), Guoqiang Lin (Author), Rui Zhang (Author), Yuting Wen (Author), Chunying Luo (Author), Ran Wang (Author), Feiyun Wang (Author), Shoujiao Peng (Author), Jiange Zhang (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bufotalin (BT), a major active constituent of Chansu, has been found to possess multiple pharmacological activities. Although previous studies have shown that BT could inhibit the growth of glioblastoma (GBM), the safety of BT in vivo and the potential mechanism are still unclear. We conducted a sys...