Cross-sectional and longitudinal associations of adherence to WCRF/AICR cancer prevention recommendations with health-related quality of life in breast cancer survivors. Health-EpiGEICAM study

• Main Authors: Virginia Lope (Author), Ángel Guerrero-Zotano (Author), Nerea Fernández de Larrea-Baz (Author), Silvia Antolín (Author), Marta Benavent Viñuales (Author), Begoña Bermejo (Author), Emma Ruiz-Moreno (Author), José Manuel Baena-Cañada (Author), Lorena París (Author), Antonio Antón (Author), José Ignacio Chacón (Author), Montserrat Muñoz (Author), José Angel García-Sáenz (Author), Clara Olier (Author), Pedro Sánchez Rovira (Author), Angels Arcusa Lanza (Author), Sonia González (Author), Joan Brunet (Author), Amparo Oltra (Author), Susana Bezares (Author), Libertad Rosell (Author), Beatriz Pérez-Gómez (Author), Roberto Pastor-Barriuso (Author), Miguel Martín (Author), Marina Pollán (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objectives: Adherence to healthy lifestyle recommendations has been reported to improve health-related quality of life (HRQL) in breast cancer (BC) patients, but the influence of long-term behavioral changes remains unknown. We evaluated the association between adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations and HRQL both, at BC diagnosis and the change 7−12 years later. Design: Prospective cohort study. Settings and participants: A total of 406 breast cancer survivors, from the EpiGEICAM study, were recruited in 16 Spanish hospitals. Measurements: Epidemiological, clinical, dietary, physical activity and HRQL information was collected both at recruitment and 7−12 years later. A 7-item score to measure compliance with recommendations was assessed according to the 2018 WCRF/AICR scoring criteria. HRQL was evaluated using SF-36 questionnaire. Linear mixed models for longitudinal data were used to assess the cross-sectional and longitudinal association between adherence score and the physical and mental component summary scores. Results: At diagnosis, for each unit increase in WCRF/AICR score adherence, the HRQL physical domain increased 0.78 points (95%CI: −0.04 to 1.60; P trend:0.06). The mean change in physical HRQL from diagnosis to follow-up per unit increase in within-subject adherence score was 0.73 points (95%CI: −0.18 to 1.65; P trend: 0.12). For the mental domain, no association was observed with compliance with the recommendations at diagnosis, nor with changes in adherence over time. Conclusions: Our results suggest that Increased adherence to WCRF/AICR cancer prevention recommendations over time could contribute to slightly improved long-term physical HRQoL in BC survivors.

Item Description

1760-4788
10.1016/j.jnha.2024.100312