Antioxidant vitamins and glycatedhaemoglobin status in sickle cell anaemia

• Autori principali: Johnkennedy Nnodim (Autore), Meludu Samuel C (Autore), Dioka C.E (Autore), Onyemailoh Obiageli Bridget (Autore), Obi Patrick Chinedu (Autore)
• Natura: Libro
• Pubblicazione: Al Ameen Medical College, 2014-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.
• Notes: 0974-1143; 0974-1143
• Keywords: Vitamins; glycatedhaemoglobin; sickle cell anemia; Therapeutics. Pharmacology; RM1-950; Toxicology. Poisons; RA1190-1270
• Source: Al Ameen Journal of Medical Sciences, Vol 7, Iss 02, Pp 175-177 (2014)

Background: Sickle cell anemiais a genetic disorder that is characterized by chronic anemia and oxidative stress. AIM: This study was investigated to evaluate the level of antioxidant vitamins C and E, and glycatedhaemoglobin in patients with homozygous sickle cell disorders (HbSS in steady state and HbSS in crisis) and normal healthy individuals (HbAA). Material and Methods: 100 sickle cell patients aged 5-30 years were included in this study while 100 normal healthy individuals served as the control. Also 30 sickle cell patients in crisis was involved. Results: This results obtained showed that the level of vitamins C and E were significantly depleted in sickle cell disease when compared with healthy individuals at p<0.05. In the same vein, the level of glycatedhaemoglobin was decreased in sickle cell disease when compared with normal healthy control. Also the levels of vitamins and glycatedhaemoglobin were significantly decreased in sickle cell crises (P<0.05). Conclusion: This shows that depleted antioxidant vitamins could be an important factor in sickle cell crisis. Hence, supplementation of sickle cell patients with vitamins can improve their health.