In a randomized trial, the live attenuated tetravalent dengue vaccine TV003 is well-tolerated and highly immunogenic in subjects with flavivirus exposure prior to vaccination.

• Main Authors: Stephen S Whitehead (Author), Anna P Durbin (Author), Kristen K Pierce (Author), Dan Elwood (Author), Benjamin D McElvany (Author), Ellen A Fraser (Author), Marya P Carmolli (Author), Cecilia M Tibery (Author), Noreen A Hynes (Author), Matthew Jo (Author), Janece M Lovchik (Author), Catherine J Larsson (Author), Elena A Doty (Author), Dorothy M Dickson (Author), Catherine J Luke (Author), Kanta Subbarao (Author), Sean A Diehl (Author), Beth D Kirkpatrick (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infection caused by the four serotypes of dengue virus (DENV-1-4) is a leading cause of mosquito-borne disease. Clinically-severe dengue disease is more common when secondary dengue infection occurs following prior infection with a heterologous dengue serotype. Other flaviviruses such as yellow feve...