Increase of CD4+CD25highFoxP3+ cells impairs in vitro human microbicidal activity against Mycobacterium tuberculosis during latent and acute pulmonary tuberculosis.

• Main Authors: Lorenzzo Lyrio Stringari (Author), Luciana Polaco Covre (Author), Flávia Dias Coelho da Silva (Author), Vivian Leite de Oliveira (Author), Maria Carolina Campana (Author), David Jamil Hadad (Author), Moisés Palaci (Author), Padmini Salgame (Author), Reynaldo Dietze (Author), Daniel Cláudio de Oliveira Gomes (Author), Rodrigo Ribeiro-Rodrigues (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Regulatory T cells (Tregs) play a critical role during Mycobacterium tuberculosis (Mtb) infection, modulating host responses while neutralizing excessive inflammation. However, their impact on regulating host protective immunity is not completely understood. Here, we d...