Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined "Complementary Lethality"

• Egile Nagusiak: Mateusz Rytelewski (Egilea), Peter J Ferguson (Egilea), Saman Maleki Vareki (Egilea), Rene Figueredo (Egilea), Mark Vincent (Egilea), James Koropatnick (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2013-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

A high mutation rate leading to tumor cell heterogeneity is a driver of malignancy in human cancers. Paradoxically, however, genomic instability can also render tumors vulnerable to therapeutic attack. Thus, targeting DNA repair may induce an intolerable level of DNA damage in tumor cells. BRCA2 med...