Understanding the genetics of systemic lupus erythematosus using Bayesian statistics and gene network analysis
The publication of genetic epidemiology meta-analyses has increased rapidly, but it has been suggested that many of the statistically significant results are false positive. In addition, most such meta-analyses have been redundant, duplicate, and erroneous, leading to research waste. In addition, si...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
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The Korean Pediatric Society,
2021-05-01T00:00:00Z.
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| 001 | doaj_e86b4a14e68d429da9bc3f48403d866d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Seoung Wan Nam |e author |
| 700 | 1 | 0 | |a Kwang Seob Lee |e author |
| 700 | 1 | 0 | |a Jae Won Yang |e author |
| 700 | 1 | 0 | |a Younhee Ko |e author |
| 700 | 1 | 0 | |a Michael Eisenhut |e author |
| 700 | 1 | 0 | |a Keum Hwa Lee |e author |
| 700 | 1 | 0 | |a Jae Il Shin |e author |
| 700 | 1 | 0 | |a Andreas Kronbichler |e author |
| 245 | 0 | 0 | |a Understanding the genetics of systemic lupus erythematosus using Bayesian statistics and gene network analysis |
| 260 | |b The Korean Pediatric Society, |c 2021-05-01T00:00:00Z. | ||
| 500 | |a 2713-4148 | ||
| 500 | |a 10.3345/cep.2020.00633 | ||
| 520 | |a The publication of genetic epidemiology meta-analyses has increased rapidly, but it has been suggested that many of the statistically significant results are false positive. In addition, most such meta-analyses have been redundant, duplicate, and erroneous, leading to research waste. In addition, since most claimed candidate gene associations were false-positives, correctly interpreting the published results is important. In this review, we emphasize the importance of interpreting the results of genetic epidemiology meta-analyses using Bayesian statistics and gene network analysis, which could be applied in other diseases. | ||
| 546 | |a EN | ||
| 690 | |a systemic lupus erythematosus | ||
| 690 | |a false-positive report probability | ||
| 690 | |a bayesian false-discovery probability | ||
| 690 | |a string database | ||
| 690 | |a protein-protein interaction | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Clinical and Experimental Pediatrics, Vol 64, Iss 5, Pp 208-222 (2021) | |
| 787 | 0 | |n http://www.e-cep.org/upload/pdf/cep-2020-00633.pdf | |
| 787 | 0 | |n https://doaj.org/toc/2713-4148 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e86b4a14e68d429da9bc3f48403d866d |z Connect to this object online. |