High triglyceride to HDL cholesterol ratio is associated with increased coronary heart disease among White but not Black adults
Objective: Black adults are less likely than White adults to present with adverse lipid profiles and more likely to present with low-grade inflammation. The impact of race on the association between atherogenic lipid profiles, inflammation, and coronary heart disease (CHD) is unknown. Methods: We ev...
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2021-09-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_e88e4a83231d474a8aa3d9c68d12bab1 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Cesar Higgins Tejera |e author |
700 | 1 | 0 | |a Jessica Minnier |e author |
700 | 1 | 0 | |a Sergio Fazio |e author |
700 | 1 | 0 | |a Monika M Safford |e author |
700 | 1 | 0 | |a Lisandro D. Colantonio |e author |
700 | 1 | 0 | |a Marguerite R Irvin |e author |
700 | 1 | 0 | |a Virginia Howard |e author |
700 | 1 | 0 | |a Neil A Zakai |e author |
700 | 1 | 0 | |a Nathalie Pamir |e author |
245 | 0 | 0 | |a High triglyceride to HDL cholesterol ratio is associated with increased coronary heart disease among White but not Black adults |
260 | |b Elsevier, |c 2021-09-01T00:00:00Z. | ||
500 | |a 2666-6677 | ||
500 | |a 10.1016/j.ajpc.2021.100198 | ||
520 | |a Objective: Black adults are less likely than White adults to present with adverse lipid profiles and more likely to present with low-grade inflammation. The impact of race on the association between atherogenic lipid profiles, inflammation, and coronary heart disease (CHD) is unknown. Methods: We evaluated the association between high levels (>50th percentile) of high-sensitivity C-reactive protein (hsCRP) and of triglycerides to high density lipoprotein ratio (TG/HDL-C) and CHD events by race in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort with 30,239 Black and White participants aged 45 and older. Results: Participants with both high hsCRP and high TG/HDL-C had highest rates of CHD (HR 1.84; 95% CI: 1.48, 2.29 vs HR 1.52; 95% CI: 1.19, 1.94 in White vs Black participants respectively). Whereas isolated high hsCRP was associated with increased CHD risk in both races (HR 1.68; 95% CI: 1.31, 2.15 and HR 1.43; 95% CI: 1.13, 1.81 for White and Black participants respectively), isolated high TG/HDL was associated with increased CHD risk only in White participants (HR 1.44; 95% CI: 1.15, 1.79 vs HR 1.01; 95% CI: 0.74, 1.38). Further, the effects of high hsCRP and high TG/HDL-C were additive, with inflammation being the driving variable for the association in both races. Conclusion: In both races, higher inflammation combined with adverse lipid profile is associated with greater CHD risk. Therefore, inflammation increases CHD risk in both races whereas dyslipidemia alone is associated with a greater risk in White but not in Black adults. hsCRP testing should be a standard feature of CHD risk assessment, particularly in Black patients. | ||
546 | |a EN | ||
690 | |a TG/HDL ratio | ||
690 | |a Dyslipidemia | ||
690 | |a CAD | ||
690 | |a CHD | ||
690 | |a Vascular Inflammation | ||
690 | |a hsCRP | ||
690 | |a Diseases of the circulatory (Cardiovascular) system | ||
690 | |a RC666-701 | ||
690 | |a Public aspects of medicine | ||
690 | |a RA1-1270 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n American Journal of Preventive Cardiology, Vol 7, Iss , Pp 100198- (2021) | |
787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2666667721000520 | |
787 | 0 | |n https://doaj.org/toc/2666-6677 | |
856 | 4 | 1 | |u https://doaj.org/article/e88e4a83231d474a8aa3d9c68d12bab1 |z Connect to this object online. |