Gender Features and Clinical and Prognostic Significance of Neurogenic and Allergic Inflammation Markers in Children with Bronchial Asthma
The article analyzes the gender and clinical and prognostic significance of substance P (subst. P), vasoactive intestinal peptide (VIP) as a markers of neurogenic inflammation and interleukins (IL) 2, 4, 5 and interferon-gamma (IFN-gamma) as markers of allergic inflammation in 34 children with bronc...
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Zaslavsky O.Yu.,
2014-10-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_e8d6454f9bc84aef8c8b8e6a6d52014f | ||
042 | |a dc | ||
100 | 1 | 0 | |a S.M. Nedelska |e author |
700 | 1 | 0 | |a O.Yu. Akulova |e author |
700 | 1 | 0 | |a I.V. Solodova |e author |
700 | 1 | 0 | |a V.I. Mazur |e author |
245 | 0 | 0 | |a Gender Features and Clinical and Prognostic Significance of Neurogenic and Allergic Inflammation Markers in Children with Bronchial Asthma |
260 | |b Zaslavsky O.Yu., |c 2014-10-01T00:00:00Z. | ||
500 | |a 2224-0551 | ||
500 | |a 2307-1168 | ||
500 | |a 10.22141/2224-0551.7.58.2014.75807 | ||
520 | |a The article analyzes the gender and clinical and prognostic significance of substance P (subst. P), vasoactive intestinal peptide (VIP) as a markers of neurogenic inflammation and interleukins (IL) 2, 4, 5 and interferon-gamma (IFN-gamma) as markers of allergic inflammation in 34 children with bronchial asthma (BA) aged 10-17 years. The concentration of these markers was determined in blood serum by ELISA twice - in uncontrolled and controlled course of BA. It is proved that the levels of neuropeptide Subst. P and IL-2, IL-4, IFN-gamma had no gender differences and did not reflect the degree of BA control. Analysis of VIP and IL-5 levels revealed a gender dependence of their fluctuations: VIP level was statistically lower, and IL-5 level - higher in boys with uncontrolled BA forms as compared to healthy boys. It can be assumed that the tendency to BA and a higher incidence of BA in boys is associated with reduced VIP levels as a bronchodilator and increased levels of IL-5 as interleukin of allergic inflammation. Upon reaching control over BA course, there was observed an increase in VIP level and decrease in IL-5 level to levels of appropriate indicators in healthy children, regardless of the duration of the disease. Determination of VIP and IL-5 levels can be used as diagnostic markers for efficacy of treatment being carried out and the degree of BA course controllability. | ||
546 | |a EN | ||
546 | |a UK | ||
690 | |a bronchial asthma | ||
690 | |a children | ||
690 | |a neuropeptides | ||
690 | |a interleukins. | ||
690 | |a Pediatrics | ||
690 | |a RJ1-570 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Zdorovʹe Rebenka, Vol 9, Iss 7.58, Pp 43-47 (2014) | |
787 | 0 | |n http://childshealth.zaslavsky.com.ua/article/view/75807 | |
787 | 0 | |n https://doaj.org/toc/2224-0551 | |
787 | 0 | |n https://doaj.org/toc/2307-1168 | |
856 | 4 | 1 | |u https://doaj.org/article/e8d6454f9bc84aef8c8b8e6a6d52014f |z Connect to this object online. |