Gender Features and Clinical and Prognostic Significance of Neurogenic and Allergic Inflammation Markers in Children with Bronchial Asthma

The article analyzes the gender and clinical and prognostic significance of substance P (subst. P), vasoactive intestinal peptide (VIP) as a markers of neurogenic inflammation and interleukins (IL) 2, 4, 5 and interferon-gamma (IFN-gamma) as markers of allergic inflammation in 34 children with bronc...

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Main Authors: S.M. Nedelska (Author), O.Yu. Akulova (Author), I.V. Solodova (Author), V.I. Mazur (Author)
Format: Book
Published: Zaslavsky O.Yu., 2014-10-01T00:00:00Z.
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042 |a dc 
100 1 0 |a S.M. Nedelska  |e author 
700 1 0 |a O.Yu. Akulova  |e author 
700 1 0 |a I.V. Solodova  |e author 
700 1 0 |a V.I. Mazur  |e author 
245 0 0 |a Gender Features and Clinical and Prognostic Significance of Neurogenic and Allergic Inflammation Markers in Children with Bronchial Asthma 
260 |b Zaslavsky O.Yu.,   |c 2014-10-01T00:00:00Z. 
500 |a 2224-0551 
500 |a 2307-1168 
500 |a 10.22141/2224-0551.7.58.2014.75807 
520 |a The article analyzes the gender and clinical and prognostic significance of substance P (subst. P), vasoactive intestinal peptide (VIP) as a markers of neurogenic inflammation and interleukins (IL) 2, 4, 5 and interferon-gamma (IFN-gamma) as markers of allergic inflammation in 34 children with bronchial asthma (BA) aged 10-17 years. The concentration of these markers was determined in blood serum by ELISA twice - in uncontrolled and controlled course of BA. It is proved that the levels of neuropeptide Subst. P and IL-2, IL-4, IFN-gamma had no gender differences and did not reflect the degree of BA control. Analysis of VIP and IL-5 levels revealed a gender dependence of their fluctuations: VIP level was statistically lower, and IL-5 level - higher in boys with uncontrolled BA forms as compared to healthy boys. It can be assumed that the tendency to BA and a higher incidence of BA in boys is associated with reduced VIP levels as a bronchodilator and increased levels of IL-5 as interleukin of allergic inflammation. Upon reaching control over BA course, there was observed an increase in VIP level and decrease in IL-5 level to levels of appropriate indicators in healthy children, regardless of the duration of the disease. Determination of VIP and IL-5 levels can be used as diagnostic markers for efficacy of treatment being carried out and the degree of BA course controllability. 
546 |a EN 
546 |a UK 
690 |a bronchial asthma 
690 |a children 
690 |a neuropeptides 
690 |a interleukins. 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Zdorovʹe Rebenka, Vol 9, Iss 7.58, Pp 43-47 (2014) 
787 0 |n http://childshealth.zaslavsky.com.ua/article/view/75807 
787 0 |n https://doaj.org/toc/2224-0551 
787 0 |n https://doaj.org/toc/2307-1168 
856 4 1 |u https://doaj.org/article/e8d6454f9bc84aef8c8b8e6a6d52014f  |z Connect to this object online.