Targeting Wnt Signaling in the Tumor Immune Microenvironment to Enhancing EpCAM CAR T-Cell therapy

• Main Authors: Weizhen Li (Author), Yang Zhou (Author), Zhongen Wu (Author), Yaoping Shi (Author), Enming Tian (Author), Yingqi Zhu (Author), Tao Wang (Author), Wei Dou (Author), Xiangjing Meng (Author), Ming Chen (Author), Bo Zhai (Author), Di Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal cancer (CRC) patients are still lacking viable treatments. Chimeric antigen receptor (CAR) T cells have shown promise in hematologic malignancies, but their efficacy in solid tumors has been limited due to the immunosuppressive tumor microenvironment. We found that cancer antigen- EpCAM e...