Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors

• Main Authors: Qing-Wen Zhang (Author), Zi-Dan Ye (Author), Chang Shen (Author), Hong-Xia Tie (Author), Lei Wang (Author), Lei Shi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HGF/c-Met signalling pathway plays an important role in the development of cancers. A series of 6,7-dimethoxy-4-anilinoquinolines possessing benzimidazole moiety were synthesised and identified as potent inhibitors of the tyrosine kinase c-Met. Their in vitro biological activities against three canc...