HLA-B60 and HLA-DR4 alleles in Javanese children with steroid-sensitive primary nephrotic syndrome
Background Steroid-sensitive nephrotic syndrome (SSNS) of children is associated with several human leucocyte antigen (HLA) class I and class II. Objective To investigate the association between HLA-B60 and HLA-DR4 alleles and primary nephrotic syndrome (PNS) in Javanese children. Methods A case con...
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Indonesian Pediatric Society Publishing House,
2016-10-01T00:00:00Z.
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| Summary: | Background Steroid-sensitive nephrotic syndrome (SSNS) of children is associated with several human leucocyte antigen (HLA) class I and class II. Objective To investigate the association between HLA-B60 and HLA-DR4 alleles and primary nephrotic syndrome (PNS) in Javanese children. Methods A case control study was conducted on 47 Javanese children with PNS who were typed for HLA-B60 and HLA-DR4 al- leles, using DNA sequence specific oligonucleotide probe (SSOP) as control sample, 47 healthy children were also typed for those HLA antigens using the same technique. Results Compared with control group, children with PNS had higher frequency of both HLA-B60 (23.32% vs 4.3%; OR=6.85 [CI=1.32- 35.65]; P<0.01) and HLA-DR4 (40.0% vs 2.1%; OR=30.67 [CI:3.71- 253.33]; P<0.0002). There was association between HLA and PNS with SSNS in children. Conclusion The strong association between PNS and HLA anti- gen support the immunogenetic background of the disease, which seems to be stronger in young children with SSNS. |
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| Item Description: | 0030-9311 2338-476X 10.14238/pi46.6.2006.246-9 |