The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy
Background. Heartburn and acid reflux (HB/RF) are associated with increased severity of nausea and vomiting. The ability of acid-reducing drugs to reduce symptoms of nausea and vomiting of pregnancy has not been previously tested. Objective. To determine whether acid-reducing pharmacotherapy decreas...
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| Main Authors: | , , , |
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| Format: | Book |
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Hindawi Limited,
2009-01-01T00:00:00Z.
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| Summary: | Background. Heartburn and acid reflux (HB/RF) are associated with increased severity of nausea and vomiting. The ability of acid-reducing drugs to reduce symptoms of nausea and vomiting of pregnancy has not been previously tested. Objective. To determine whether acid-reducing pharmacotherapy decreases the severity of NVP symptoms. Methods. We studied a cohort of women experiencing NVP, who were also experiencing HB/RF. Women were counseled to commence acid-reducing pharmacotherapy. The effectiveness of the acid-reducing medication in decreasing symptoms of both HB/RF and NVP was measured. Results. Acid-reducing drugs resulted in significant decreases in PUQE (9.6±3.0 to 6.5±2.5, P<.0001) and well-being scores from the initial (4.0±2.0) to the follow-up interview (6.8±1.6, P<.0001). After intervention with acid-reducing pharmacotherapy, a reduction in acid symptoms correlated significantly with reduction in NVP (R2=0.72, P<.001). Conclusion. This is the first study to demonstrate that management of HB/RF can reduce the severity of NVP. |
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| Item Description: | 1687-9589 1687-9597 10.1155/2009/585269 |