Transcriptome-Wide Analysis of Human Liver Reveals Age-Related Differences in the Expression of Select Functional Gene Clusters and Evidence for a PPP1R10-Governed 'Aging Cascade'

• Main Authors: Thomas Schreiter (Author), Robert K. Gieseler (Author), Ramiro Vílchez-Vargas (Author), Ruy Jauregui (Author), Jan-Peter Sowa (Author), Susanne Klein-Scory (Author), Ruth Broering (Author), Roland S. Croner (Author), Jürgen W. Treckmann (Author), Alexander Link (Author), Ali Canbay (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A transcriptome-wide analysis of human liver for demonstrating differences between young and old humans has not yet been performed. However, identifying major age-related alterations in hepatic gene expression may pinpoint ontogenetic shifts with important hepatic and systemic consequences, provide...