Regulation of hepatic glutamine metabolism by miR-122

• Main Authors: Dipanwita Sengupta (Author), Teresa Cassel (Author), Kun-yu Teng (Author), Mona Aljuhani (Author), Vivek K. Chowdhary (Author), Peng Hu (Author), Xiaoli Zhang (Author), Teresa W.-M. Fan (Author), Kalpana Ghoshal (Author)
• Format: Book
• Published: Elsevier, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: It is well established that the liver-specific miR-122, a bona fide tumor suppressor, plays a critical role in lipid homeostasis. However, its role, if any, in amino acid metabolism has not been explored. Since glutamine (Gln) is a critical energy and anaplerotic source for mammalian cell...