A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma

Background. Multiple modalities have been used in the treatment of melasma with variable success. Niacinamide has anti-inflammatory properties and is able to decrease the transfer of melanosomes. Objective. To evaluate the therapeutic effect of topical niacinamide versus hydroquinone (HQ) in melasma...

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Main Authors: Josefina Navarrete-Solís (Author), Juan Pablo Castanedo-Cázares (Author), Bertha Torres-µlvarez (Author), Cuauhtemoc Oros-Ovalle (Author), Cornelia Fuentes-Ahumada (Author), Francisco Javier González (Author), Juan David Martínez-Ramírez (Author), Benjamin Moncada (Author)
Format: Book
Published: Hindawi Limited, 2011-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Josefina Navarrete-Solís  |e author 
700 1 0 |a Juan Pablo Castanedo-Cázares  |e author 
700 1 0 |a Bertha Torres-µlvarez  |e author 
700 1 0 |a Cuauhtemoc Oros-Ovalle  |e author 
700 1 0 |a Cornelia Fuentes-Ahumada  |e author 
700 1 0 |a Francisco Javier González  |e author 
700 1 0 |a Juan David Martínez-Ramírez  |e author 
700 1 0 |a Benjamin Moncada  |e author 
245 0 0 |a A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma 
260 |b Hindawi Limited,   |c 2011-01-01T00:00:00Z. 
500 |a 1687-6105 
500 |a 1687-6113 
500 |a 10.1155/2011/379173 
520 |a Background. Multiple modalities have been used in the treatment of melasma with variable success. Niacinamide has anti-inflammatory properties and is able to decrease the transfer of melanosomes. Objective. To evaluate the therapeutic effect of topical niacinamide versus hydroquinone (HQ) in melasma patients. Patients and Methods. Twenty-seven melasma patients were randomized to receive for eight weeks 4% niacinamide cream on one side of the face, and 4% HQ cream on the other. Sunscreen was applied along the observation period. They were assessed by noninvasive techniques for the evaluation of skin color, as well as subjective scales and histological sections initially and after the treatment with niacinamide. Results. All patients showed pigment improvement with both treatments. Colorimetric measures did not show statistical differences between both sides. However, good to excellent improvement was observed with niacinamide in 44% of patients, compared to 55% with HQ. Niacinamide reduced importantly the mast cell infiltrate and showed improvement of solar elastosis in melasma skin. Side effects were present in 18% with niacinamide versus 29% with HQ. Conclusion. Niacinamide induces a decrease in pigmentation, inflammatory infiltrate, and solar elastosis. Niacinamide is a safe and effective therapeutic agent for this condition. 
546 |a EN 
690 |a Dermatology 
690 |a RL1-803 
655 7 |a article  |2 local 
786 0 |n Dermatology Research and Practice, Vol 2011 (2011) 
787 0 |n http://dx.doi.org/10.1155/2011/379173 
787 0 |n https://doaj.org/toc/1687-6105 
787 0 |n https://doaj.org/toc/1687-6113 
856 4 1 |u https://doaj.org/article/e97a19d4f56c4a5c97a6f6ea3889fa2d  |z Connect to this object online.