Antimycobacterial Activity of <i>Hedeoma drummondii</i> against <i>Mycobacterium tuberculosis</i> and Non-Tuberculous Mycobacteria

• Main Authors: Carmen Molina-Torres (Author), Carlos Pedraza-Rodríguez (Author), Lucio Vera-Cabrera (Author), Jorge Ocampo-Candiani (Author), Catalina Rivas-Morales (Author), Ezequiel Viveros-Valdez (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Tuberculosis (TB) remains a major health problem worldwide, and the emergence of multi-resistant strains to first-line drugs has become the biggest obstacle to its treatment. On the other hand, the incidence of non-tuberculous mycobacteria (NTM) in humans has increased remarkably in recent years. The search for new and better treatments against mycobacterial infections is a constant at the global level. Hence, in this study, we propose to investigate the antimycobacterial effect of the extracts and major compounds of <i>Hedeoma drummondii</i> against clinical isolates of <i>Mycobacterium tuberculosis</i> and non-tuberculous mycobacteria: <i>M. abscessus</i>, <i>M. fortuitum</i>, <i>M. intracellulare</i>, and <i>M. gordonae</i>. To determine the antimycobacterial activity, a microdilution assay was used to establish the minimum inhibitory concentration (MIC) of the different strains of <i>Mycobacterium</i>. The methanolic extract presented the best activity against <i>M. tuberculosis</i>, inhibiting ten of the twelve strains analyzed at a concentration < 2500 µg/mL; meanwhile, the hexanic extract presented the best activity against non-tuberculous mycobacteria (NTM) by inhibiting eight of the ten strains studied at ≤625 µg/mL. Moreover, there is a strong positive correlation between the antimycobacterial activity of pulegone and the hexanic extract against non-tuberculous strains, so this compound could serve as a predictability marker against these types of microorganisms.

Item Description

10.3390/antibiotics12050833
2079-6382