Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis

• Main Authors: Seongin Jo (Author), Young-Sung Jung (Author), Ye-Ryeong Cho (Author), Ji-Won Seo (Author), Won-Chul Lim (Author), Tae-Gyu Nam (Author), Tae-Gyu Lim (Author), Sanguine Byun (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/antiox10111663; 2076-3921
• Keywords: <i>Rosa gallica</i>; skin aging; gallic acid; c−Raf; UHPLC−MS/MS; Therapeutics. Pharmacology; RM1-950
• Source: Antioxidants, Vol 10, Iss 11, p 1663 (2021)

<i>Rosa gallica</i> is a widely used Rosa species for medicinal and culinary purposes. <i>Rosa gallica</i> has been reported to display antioxidant, anti−inflammatory, and antibacterial activities. However, the effect of <i>Rosa gallica</i> against skin aging in vivo is unknown and its active components have not been fully understood. Oral administration of <i>Rosa gallica</i> prevented UVB−mediated skin wrinkle formation and loss of collagen/keratin fibers in the dorsal skin of mice. Examination of biomarkers at the molecular level showed that <i>Rosa gallica</i> downregulates UVB−induced COX−2 and MMP−1 expression in the skin. Through a direct comparison of major compounds identified using the UHPLC−MS/MS system, we discovered gallic acid as the primary component contributing to the anti-skin aging effect exhibited by <i>Rosa gallica</i>. Examination of the molecular mechanism revealed that gallic acid can potently and selectively target the c−Raf/MEK/ERK/c−Fos signaling axis. In addition, both gallic acid and MEK inhibitor blocked UVB−induced MMP−1 expression and restored collagen levels in a reconstructed 3D human skin model. Collectively, <i>Rosa gallica</i> could be used as a functional ingredient in the development of nutraceuticals against skin aging.