Do High Doses of Multiple Antibiotics Loaded into Bone Cement Spacers Improve the Success Rate in Staphylococcal Periprosthetic Joint Infection When Rifampicin Cannot Be Employed?

• Main Authors: Lourdes Prats-Peinado (Author), Tanya Fernández-Fernández (Author), Miguel Márquez-Gómez (Author), José Antonio Matas-Diaz (Author), Mar Sánchez-Somolinos (Author), Sofía de la Villa-Martínez (Author), Javier Vaquero-Martín (Author), Pablo Sanz-Ruiz (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rifampicin is one of the mainstays in treating staphylococcal prosthetic joint infection (PJI). However, discontinuation due to intolerance, drug interactions, and adverse events is common. Two-stage revision surgery remains the gold standard, with the number of revision arthroplasties steadily incr...