Separating clinical antibodies from repertoire antibodies, a path to in silico developability assessment

• मुख्य लेखकों: Christopher Negron (लेखक), Joyce Fang (लेखक), Michael J. McPherson (लेखक), W. Blaine Stine (लेखक), Andrew J. McCluskey (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Approaches for antibody discovery have seen substantial improvement and success in recent years. Yet, advancing antibodies into the clinic remains difficult because therapeutic developability concerns are challenging to predict. We developed a computational model to simplify antibody developability...