Role of heme oxygenase-1 in tumor immune escape
The inducible enzyme heme oxygenase 1 (HO-1) plays a pivotal role in cell defense against different kind of stressors, from oxidative stress to hypoxia. For this reason, HO-1 overexpression has been correlated to cancer aggressiveness in different tumors, being one of the molecular mechanisms used b...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
Bioscientifica,
2023-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | The inducible enzyme heme oxygenase 1 (HO-1) plays a pivotal role in cell defense against different kind of stressors, from oxidative stress to hypoxia. For this reason, HO-1 overexpression has been correlated to cancer aggressiveness in different tumors, being one of the molecular mechanisms used by tumor cells to become r esistant to therapies. In addition, HO-1 has a well-recognized role in restraining immune response and in maintaining tolerance. In this context, the possibility that HO-1 induction in immune cells can reduce immune response to cancer and impair cancer immune therapy becomes a hot topic in cancer research. In this review, the most recent e vidence pointing out the role of HO-1 in generating a permissive tumor microenvironment has been discussed as well as the most promising therapeutic approaches to increase effectiveness of immune therapies. |
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| Item Description: | https://doi.org/10.1530/REM-23-0006 2755-158X |