Do antibody CDR loops change conformation upon binding?

• Main Authors: Chu'nan Liu (Author), Lilian M. Denzler (Author), Oliver E.C. Hood (Author), Andrew C.R. Martin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTAntibodies have increasingly been developed as drugs with over 100 now licensed in the US or EU. During development, it is often necessary to increase or reduce the affinity of an antibody and rational attempts to do so rely on having a structure of the antibody-antigen complex often obtaine...