Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study

The gamma-glutamyltransferase (GGT) is recognized in medical practice as a useful indicator for the detection of liver lesions, especially those induced by the excessive consumption of alcoholic or cholesterol-associated drinks. The present study, although it includes a very small number of cases di...

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Main Authors: Constantin Bălăeţ (Author), Bogdan Ioan Coculescu (Author), Gheorghe Manole (Author), Maria Bălăeţ (Author), Gabi Valeriu Dincă (Author)
Format: Book
Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
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100 1 0 |a Constantin Bălăeţ  |e author 
700 1 0 |a Bogdan Ioan Coculescu  |e author 
700 1 0 |a Gheorghe Manole  |e author 
700 1 0 |a Maria Bălăeţ  |e author 
700 1 0 |a Gabi Valeriu Dincă  |e author 
245 0 0 |a Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study 
260 |b Taylor & Francis Group,   |c 2018-01-01T00:00:00Z. 
500 |a 1475-6366 
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500 |a 10.1080/14756366.2018.1428802 
520 |a The gamma-glutamyltransferase (GGT) is recognized in medical practice as a useful indicator for the detection of liver lesions, especially those induced by the excessive consumption of alcoholic or cholesterol-associated drinks. The present study, although it includes a very small number of cases diagnosed with colon diverticulosis-diverticulitis associated with polyposis at the same intestinal level, identifies the presence of increased circulating concentrations of this enzyme in the serum. Its serum levels are tracked "dynamically" throughout a year after the diagnosis and start of the therapy. The study calls into question the release of the enzyme from the edge of the enterocytes' brush-like edge, leading to the pathogenic disturbance of regional redox homeostasis. The hypothesis gives the circulating values of GGT predictive value for cellular oxidative stress, as well as for indirectly expressing the glutathione level in cytosol. 
546 |a EN 
690 |a Gamma-glutamyltransferase 
690 |a inflammation marker 
690 |a colon polyposis 
690 |a oxidative stress 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 428-432 (2018) 
787 0 |n http://dx.doi.org/10.1080/14756366.2018.1428802 
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787 0 |n https://doaj.org/toc/1475-6374 
856 4 1 |u https://doaj.org/article/ea18c042076e47e99b8400d9beedf37e  |z Connect to this object online.