CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• Κύριοι συγγραφείς: Fatemeh Movahedi Motlagh (Συγγραφέας), Hamid Reza Soleimanpour‐Lichaei (Συγγραφέας), Mehdi Shamsara (Συγγραφέας), Azadeh Etemadzadeh (Συγγραφέας), Mohammad Hossein Modarressi (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...