CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• Egile Nagusiak: Fatemeh Movahedi Motlagh (Egilea), Hamid Reza Soleimanpour‐Lichaei (Egilea), Mehdi Shamsara (Egilea), Azadeh Etemadzadeh (Egilea), Mohammad Hossein Modarressi (Egilea)
• Formatua: Liburua
• Argitaratua: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...