CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• Autori principali: Fatemeh Movahedi Motlagh (Autore), Hamid Reza Soleimanpour‐Lichaei (Autore), Mehdi Shamsara (Autore), Azadeh Etemadzadeh (Autore), Mohammad Hossein Modarressi (Autore)
• Natura: Libro
• Pubblicazione: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...