CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• 主要な著者: Fatemeh Movahedi Motlagh (著者), Hamid Reza Soleimanpour‐Lichaei (著者), Mehdi Shamsara (著者), Azadeh Etemadzadeh (著者), Mohammad Hossein Modarressi (著者)
• フォーマット: 図書
• 出版事項: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...