CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• Ngā kaituhi matua: Fatemeh Movahedi Motlagh (Author), Hamid Reza Soleimanpour‐Lichaei (Author), Mehdi Shamsara (Author), Azadeh Etemadzadeh (Author), Mohammad Hossein Modarressi (Author)
• Hōputu: Pukapuka
• I whakaputaina: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...