CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• Үндсэн зохиолчид: Fatemeh Movahedi Motlagh (Зохиогч), Hamid Reza Soleimanpour‐Lichaei (Зохиогч), Mehdi Shamsara (Зохиогч), Azadeh Etemadzadeh (Зохиогч), Mohammad Hossein Modarressi (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...