CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

• Главные авторы: Fatemeh Movahedi Motlagh (Автор), Hamid Reza Soleimanpour‐Lichaei (Автор), Mehdi Shamsara (Автор), Azadeh Etemadzadeh (Автор), Mohammad Hossein Modarressi (Автор)
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• Опубликовано: Tabriz University of Medical Sciences, 2023-11-01T00:00:00Z.
• Предметы: article
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Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...