Genome-wide risk prediction of common diseases across ancestries in one million people

• Main Authors: Nina Mars (Author), Sini Kerminen (Author), Yen-Chen A. Feng (Author), Masahiro Kanai (Author), Kristi Läll (Author), Laurent F. Thomas (Author), Anne Heidi Skogholt (Author), Pietro della Briotta Parolo (Author), Benjamin M. Neale (Author), Jordan W. Smoller (Author), Maiken E. Gabrielsen (Author), Kristian Hveem (Author), Reedik Mägi (Author), Koichi Matsuda (Author), Yukinori Okada (Author), Matti Pirinen (Author), Aarno Palotie (Author), Andrea Ganna (Author), Alicia R. Martin (Author), Samuli Ripatti (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Polygenic risk scores (PRS) measure genetic disease susceptibility by combining risk effects across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast and prostate cancer, we performed cross-ancestry evaluation of genome-wide PRSs in six biobanks in Europe, the...