Oncostatin M-driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis

• Main Authors: Nam Cong-Nhat Huynh (Author), Rui Ling (Author), Masatsugu Komagamine (Author), Tianshu Shi (Author), Masayuki Tsukasaki (Author), Kotaro Matsuda (Author), Kazuo Okamoto (Author), Tatsuo Asano (Author), Ryunosuke Muro (Author), Warunee Pluemsakunthai (Author), George Kollias (Author), Yuko Kaneko (Author), Tsutomu Takeuchi (Author), Sakae Tanaka (Author), Noriko Komatsu (Author), Hiroshi Takayanagi (Author)
• Format: Book
• Published: BMC, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Recent single-cell RNA sequencing (scRNA-seq) analysis revealed the functional heterogeneity and pathogenic cell subsets in immune cells, synovial fibroblasts and bone cells in rheumatoid arthritis (RA). JAK inhibitors which ameliorate joint inflammation and bone destruction in R...