Cover Image

[<sup>99m</sup>Tc]Tc-iFAP Radioligand for SPECT/CT Imaging of the Tumor Microenvironment: Kinetics, Radiation Dosimetry, and Imaging in Patients

Tumor microenvironment fibroblasts overexpress the fibroblast activation protein (FAP). We recently reported the preclinical evaluation of [<sup>99m</sup>Tc]Tc-iFAP as a new SPECT radioligand capable of detecting FAP. This research aimed to evaluate the kinetic and dosimetric profile of...

Full description

Saved in:

Bibliographic Details
Main Authors:	Luis Coria-Domínguez (Author), Paola Vallejo-Armenta (Author), Myrna Luna-Gutiérrez (Author), Blanca Ocampo-García (Author), Brenda Gibbens-Bandala (Author), Francisco García-Pérez (Author), Gerardo Ramírez-Nava (Author), Clara Santos-Cuevas (Author), Guillermina Ferro-Flores (Author)
Format:	Book
Published:	MDPI AG, 2022-05-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

[<sup>99m</sup>Tc]Tc-iFAP/SPECT Tumor Stroma Imaging: Acquisition and Analysis of Clinical Images in Six Different Cancer Entities
by: Paola Vallejo-Armenta, et al.
Published: (2022)

[<sup>99m</sup>Tc]Tc-Labeled Plectin-Targeting Peptide as a Novel SPECT Probe for Tumor Imaging
by: Jiali Gong, et al.
Published: (2022)

<sup>99m</sup>Tc-Labeled FAPI SPECT Imaging in Idiopathic Pulmonary Fibrosis: Preliminary Results
by: Yu Liu, et al.
Published: (2023)

Toward Stability Enhancement of NTS<sub>1</sub>R-Targeted Radioligands: Structural Interventions on [<sup>99m</sup>Tc]Tc-DT1
by: Panagiotis Kanellopoulos, et al.
Published: (2023)

SPECT Imaging of SST2-Expressing Tumors with <sup>99m</sup>Tc-Based Somatostatin Receptor Antagonists: The Role of Tetraamine, HYNIC, and Spacers
by: Raghuvir Haridas Gaonkar, et al.
Published: (2021)

<sup>99m</sup>Tc-Labeled Cyclic Peptide Targeting PD-L1 as a Novel Nuclear Imaging Probe
by: Guillermina Ferro-Flores, et al.
Published: (2023)

Radiosynthesis and Preclinical Evaluation of [<sup>99m</sup>Tc]Tc-Tigecycline Radiopharmaceutical to Diagnose Bacterial Infections
by: Syeda Marab Saleem, et al.
Published: (2024)

Evaluation of Approaches for the Assessment of HER2 Expression in Breast Cancer by Radionuclide Imaging Using the Scaffold Protein [<sup>99m</sup>Tc]Tc-ADAPT6
by: Olga Bragina, et al.
Published: (2024)

Synthesis and Evaluation of <sup>99m</sup>Tc(CO)<sub>3</sub> Complexes with Ciprofloxacin Dithiocarbamate for Infection Imaging
by: Afroditi Papasavva, et al.
Published: (2024)

Synthesis and Evaluation of <sup>99m</sup>Tc-Labelled 2-Nitroimidazole Derivatives with Different Linkers for Tumour Hypoxia Imaging
by: Qing Ruan, et al.
Published: (2023)

Synthesis and Evaluation of Novel Norfloxacin Isonitrile <sup>99m</sup>Tc Complexes as Potential Bacterial Infection Imaging Agents
by: Si'an Fang, et al.
Published: (2021)

In Vitro Hemocompatibility and Genotoxicity Evaluation of Dual-Labeled [<sup>99m</sup>Tc]Tc-FITC-Silk Fibroin Nanoparticles for Biomedical Applications
by: María Alejandra Asensio Ruiz, et al.
Published: (2023)

Radiolabeling and Biological Evaluation of Novel <sup>99m</sup>Tc-Nitrido and <sup>99m</sup>Tc-Oxo Complexes with 4-Methoxy-<sub><span style="font-variant: small-caps">L</span></sub>-Phenylalanine Dithiocarbamate for Tumor Imaging
by: Guangxing Yin, et al.
Published: (2022)

Pharmacokinetic Imaging Using <sup>99m</sup>Tc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats
by: Solène Marie, et al.
Published: (2022)

Initial Experience of Clinical Use of [<sup>99m</sup>Tc]Tc-PSMA-T4 in Patients with Prostate Cancer. A Pilot Study
by: Jarosław B. Ćwikła, et al.
Published: (2021)

Phase I Clinical Trial Using [<sup>99m</sup>Tc]Tc-1-thio-D-glucose for Diagnosis of Lymphoma Patients
by: Vladimir Chernov, et al.
Published: (2022)

Synthesis and Biodistribution of <sup>99m</sup>Tc-Labeled PLGA Nanoparticles by Microfluidic Technique
by: Michela Varani, et al.
Published: (2021)

One Step Closer to Clinical Translation: Enhanced Tumor Targeting of [<sup>99m</sup>Tc]Tc-DB4 and [<sup>111</sup>In]In-SG4 in Mice Treated with Entresto
by: Panagiotis Kanellopoulos, et al.
Published: (2020)

Application of <sup>99m</sup>Tc-Labeled WL12 Peptides as a Tumor PD-L1-Targeted SPECT Imaging Agent: Kit Formulation, Preclinical Evaluation, and Study on the Influence of Coligands
by: Mingxuan Fan, et al.
Published: (2024)

Preparation and Bioevaluation of Novel <sup>99m</sup>Tc-Labeled Complexes with a 2-Nitroimidazole HYNIC Derivative for Imaging Tumor Hypoxia
by: Qing Ruan, et al.
Published: (2021)

Validation of Pharmacological Protocols for Targeted Inhibition of Canalicular MRP2 Activity in Hepatocytes Using [<sup>99m</sup>Tc]mebrofenin Imaging in Rats
by: Solène Marie, et al.
Published: (2020)

Preparation and Bioevaluation of a Novel <sup>99m</sup>Tc-Labeled Glucose Derivative Containing Cyclohexane as a Promising Tumor Imaging Agent
by: Junhong Feng, et al.
Published: (2023)

Optimization of the Pharmacokinetic Profile of [<sup>99m</sup>Tc]Tc-N<sub>4</sub>-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence
by: Thomas Günther, et al.
Published: (2022)

Imaging-Based Characterization of a <i>Slco2b1<sup>(-/-)</sup></i> Mouse Model Using [<sup>11</sup>C]Erlotinib and [<sup>99m</sup>Tc]Mebrofenin as Probe Substrates
by: Solène Marie, et al.
Published: (2021)

Different PSMA Radiopharmaceuticals: A Comparative Study of [<sup>18</sup>F]F-PSMA-1007, [<sup>18</sup>F]F-JK-PSMA-7, and [<sup>99m</sup>Tc]Tc-PSMA-I&S in the Skeletal System
by: Zsófia Sára Mikó, et al.
Published: (2024)

Inhibition of the Hepatic Uptake of <sup>99m</sup>Tc-Tetrofosmin Using an Organic Cation Transporter Blocker
by: Kodai Nishi, et al.
Published: (2021)

Treatment of [99mTc]Tc‐hydroxy‐diphosphonate ([99mTc]Tc‐HDP) extravasation using hyaluronidase
by: Kevin R. Doornhof, et al.
Published: (2024)

SPECT/CT imaging of chemotherapy-induced tumor apoptosis using 99mTc-labeled dendrimer-entrapped gold nanoparticles
by: Yan Xing, et al.
Published: (2018)

SPECT Imaging with Tc-99m-Labeled HYNIC-FAPI-04 to Extend the Differential Time Window in Evaluating Tumor Fibrosis
by: Xiu Luo, et al.
Published: (2023)

Preclinical Evaluation of <sup>99m</sup>Tc-Labeled GRPR Antagonists maSSS/SES-PEG<sub>2</sub>-RM26 for Imaging of Prostate Cancer
by: Ayman Abouzayed, et al.
Published: (2021)

The role of digital mammography, scintimammography with <sup>99m </sup>Tc-methoxyisobutylisonitrile (MIBI) and ultrasound in the diagnosis of multicentric breast cancer
by: A. V. Chernaya, et al.
Published: (2020)

Contribution of Tc-99m RBC SPECT/ CT in Intrahepatic and Peritoneal Splenosis Mimicking Malignancy
by: Kevser Oksuzoglu, et al.
Published: (2017)

First-in-human study of a novel cell death tracer [99mTc]Tc-Duramycin: safety, biodistribution and radiation dosimetry in healthy volunteers
by: Taco Metelerkamp Cappenberg, et al.
Published: (2023)

Localization of <sup>99m</sup>Tc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses
by: Aikaterini Kaloudi, et al.
Published: (2019)

Comparative Evaluation of Radiochemical and Biological Properties of <sup>131</sup>I- and [<sup>99m</sup>Tc]Tc(CO)<sub>3</sub>-Labeled RGD Analogues Planned to Interact with the α<sub>v</sub>β<sub>3</sub> Integrin Expressed in Glioblastoma
by: Danielle V. Sobral, et al.
Published: (2022)

Development of the <sup>99m</sup>Tc-Labelled SST<sub>2</sub> Antagonist TECANT-1 for a First-in-Man Multicentre Clinical Study
by: Doroteja Novak, et al.
Published: (2023)

Selection of the First <sup>99m</sup>Tc-Labelled Somatostatin Receptor Subtype 2 Antagonist for Clinical Translation-Preclinical Assessment of Two Optimized Candidates
by: Melpomeni Fani, et al.
Published: (2020)

Simultaneous Visualization of <sup>161</sup>Tb- and <sup>177</sup>Lu-Labeled Somatostatin Analogues Using Dual-Isotope SPECT Imaging
by: Francesca Borgna, et al.
Published: (2021)

SPECT Imaging of <i>P. aeruginosa</i> Infection in Mice Using <sup>123</sup>I-BMIPP
by: Yuri Nishiyama, et al.
Published: (2024)

A retrospective study of SPECT/CT scans using SUV measurement of the normal pelvis with Tc-99m methylene diphosphonate
by: Ruifeng Wang, et al.
Published: (2018)