Data Heterogeneity: The Enzyme to Catalyze Translational Bioinformatics?

• Huvudupphovsmän: Cahan, Eli M (Författare, medförfattare), Khatri, Purvesh (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: JMIR Publications, 2020-08-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.
• Notes: 1438-8871; 10.2196/18044
• Keywords: Computer applications to medicine. Medical informatics; R858-859.7; Public aspects of medicine; RA1-1270
• Source: Journal of Medical Internet Research, Vol 22, Iss 8, p e18044 (2020)

Up to 95% of novel interventions demonstrating significant effects at the bench fail to translate to the bedside. In recent years, the windfalls of "big data" have afforded investigators more substrate for research than ever before. However, issues with translation have persisted: although countless biomarkers for diagnostic and therapeutic targeting have been proposed, few of these generalize effectively. We assert that inadequate heterogeneity in datasets used for discovery and validation causes their nonrepresentativeness of the diversity observed in real-world patient populations. This nonrepresentativeness is contrasted with advantages rendered by the solicitation and utilization of data heterogeneity for multisystemic disease modeling. Accordingly, we propose the potential benefits of models premised on heterogeneity to promote the Institute for Healthcare Improvement's Triple Aim. In an era of personalized medicine, these models can confer higher quality clinical care for individuals, increased access to effective care across all populations, and lower costs for the health care system.