Natural Phaeosphaeride A Derivatives Overcome Drug Resistance of Tumor Cells and Modulate Signaling Pathways

• Main Authors: Victoria Abzianidze (Author), Natalia Moiseeva (Author), Diana Suponina (Author), Sofya Zakharenkova (Author), Nadezhda Rogovskaya (Author), Lidia Laletina (Author), Alvin A. Holder (Author), Denis Krivorotov (Author), Alexander Bogachenkov (Author), Alexander Garabadzhiu (Author), Anton Ukolov (Author), Vyacheslav Kosorukov (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present study, natural phaeosphaeride A (PPA) derivatives are synthesized. Anti-tumor studies are carried out on the PC3, K562, HCT-116, THP-1, MCF-7, A549, NCI-H929, Jurkat, and RPMI8226 tumor cell lines, and on the human embryonic kidney (HEK293) cell line. All the compounds synthesized tur...