Inhibition and Induction by Poziotinib of Different Rat Cytochrome P450 Enzymes In Vivo and in an In Vitro Cocktail Method

• Main Authors: Jinhui Wang (Author), Feifei Chen (Author), Hui Jiang (Author), Jia Xu (Author), Deru Meng (Author), Peiwu Geng (Author), Dapeng Dai (Author), Jingbo Hu (Author), Yunfang Zhou (Author), Quan Zhou (Author), Shuanghu Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Poziotinib is an orally active, irreversible, pan-HER tyrosine kinase inhibitor used to treat non-small cell lung cancer, breast cancer, and gastric cancer. Poziotinib is currently under clinical investigation, and understanding its drug-drug interactions is extremely important for its future develo...