Cover Image

Human Lung Cancer (A549) Cell Line Cytotoxicity and Anti-<i>Leishmania major</i> Activity of <i>Carissa macrocarpa</i> Leaves: A Study Supported by UPLC-ESI-MS/MS Metabolites Profiling and Molecular Docking

Lung cancer and cutaneous leishmaniasis are critical diseases with a relatively higher incidence in developing countries. In this research, the activity of <i>Carissa macrocarpa</i> leaf hydromethanolic extract and its solvent-fractions (<i>n</i>-hexane, EtOAc, <i>n<...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mohamed A. A. Orabi (Author), Omaish Salman Alqahtani (Author), Bandar A. Alyami (Author), Ahmed Abdullah Al Awadh (Author), El-Shaymaa (Author), Katsuyoshi Matsunami (Author), Dalia I. Hamdan (Author), Mohamed E. Abouelela (Author)
Format:	Book
Published:	MDPI AG, 2022-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

<i>Carissa macrocarpa</i> Leaves Polar Fraction Ameliorates Doxorubicin-Induced Neurotoxicity in Rats via Downregulating the Oxidative Stress and Inflammatory Markers
by: Mohamed A. A. Orabi, et al.
Published: (2021)

UPLC-ESI-MS/MS Based Characterization of Active Flavonoids from <i>Apocynum</i> spp. and Anti-Bacteria Assay
by: Gang Gao, et al.
Published: (2021)

HPLC-PDA-ESI-MS/MS Profiling and Anti-Biofilm Potential of <i>Eucalyptus</i><i>sideroxylon</i> Flowers
by: Mona M. Okba, et al.
Published: (2021)

UPLC-ESI/MS/MS Profiling and Anti-Inflammatory Activity of Gleditsia caspica
by: Hager Ashraf, et al.
Published: (2020)

Evaluation of the Antioxidant, Antimicrobial, and Anti-Biofilm Effects of the Stem Bark, Leaf, and Seed Extracts from <i>Hymenaea courbaril</i> and Characterization by UPLC-ESI-QTOF-MS/MS Analysis
by: Jhonatas Emílio Ribeiro da Cruz, et al.
Published: (2023)

UPLC-ESI-Q-TOF-MS-Based Metabolite Profiling, Antioxidant and Anti-Inflammatory Properties of Different Organ Extracts of <i>Abeliophyllum distichum</i>
by: Tong-Kewn Yoo, et al.
Published: (2021)

Identification of Compounds of <i>Crocus sativus</i> by GC-MS and HPLC/UV-ESI-MS and Evaluation of Their Antioxidant, Antimicrobial, Anticoagulant, and Antidiabetic Properties
by: Aziz Drioiche, et al.
Published: (2023)

Metabolomics-Based Profiling of <i>Clerodendrum speciosum</i> (Lamiaceae) Leaves Using LC/ESI/MS-MS and In Vivo Evaluation of Its Antioxidant Activity Using <i>Caenorhabditis elegans</i> Model
by: Fadia S. Youssef, et al.
Published: (2022)

UPLC-ESI-MS/MS and Various Chromatographic Technique for Identification of Phytochemicals in Populus euphratica Oliv. Leaves Extract
by: Mohammed A. Ezghayer, et al.
Published: (2020)

Insights into <i>Clematis cirrhosa</i> L. Ethanol Extract: Cytotoxic Effects, LC-ESI-QTOF-MS/MS Chemical Profiling, Molecular Docking, and Acute Toxicity Study
by: Manal I. Alruwad, et al.
Published: (2024)

UHPLC-ESI-QTOF-MS/MS-Based Molecular Networking Guided Isolation and Dereplication of Antibacterial and Antifungal Constituents of <i>Ventilago denticulata</i>
by: Muhaiminatul Azizah, et al.
Published: (2020)

Prediction of α-Glucosidase Inhibitory Activity of LC-ESI-TQ-MS/MS-Identified Compounds from <i>Tradescantia pallida</i> Leaves
by: Fariha Imtiaz, et al.
Published: (2022)

Profiling the Phytochemicals of <i>Orostachys margaritifolia</i>: Biological Activities, LC-ESI/MS, and HPLC Analyses
by: Nari Yoon, et al.
Published: (2024)

Metabolic profiling of Vitex Pubescens Vahl bark via UPLC-ESI-QTOF/MS/MS analysis and evaluation of its antioxidant and acetylcholinesterase inhibitory activities
by: Safa Abdelbaset, et al.
Published: (2024)

Isolation, Structural Characterization and Identification of Major Constituents in Ephedra foliata Naturally Growing in Iraq by TLC, GC-MS and UPLC-ESI-MS/MS
by: Ahmed S. Khaleefa, et al.
Published: (2020)

Acyl Quinic Acid Derivatives Screened Out from <i>Carissa spinarum</i> by SOD-Affinity Ultrafiltration LC-MS and Their Antioxidative and Hepatoprotective Activities
by: Ye Liu, et al.
Published: (2021)

Fabric phase sorptive extraction coupled with UPLC-ESI-MS/MS method for fast and sensitive quantitation of tadalafil in a bioequivalence study
by: Sameh A. Ahmed, et al.
Published: (2022)

Bioaffinity Ultrafiltration Combined with HPLC-ESI-qTOF-MS/MS for Screening Potential Bioactive Components from the Stems of <i>Dendrobium fimbriatum</i> and In Silico Analysis
by: Yu-Hui Hsieh, et al.
Published: (2024)

Identification and Antioxidant Capacity of Free and Bound Phenolics in Six Varieties of Mulberry Seeds Using UPLC-ESI-QTOF-MS/MS
by: Huaqi Gao, et al.
Published: (2022)

Flowers and Leaves Extracts of <i>Stachys palustris</i> L. Exhibit Stronger Anti-Proliferative, Antioxidant, Anti-Diabetic, and Anti-Obesity Potencies than Stems and Roots Due to More Phenolic Compounds as Revealed by UPLC-PDA-ESI-TQD-MS/MS
by: Sabina Lachowicz-Wiśniewska, et al.
Published: (2022)

Metabolite Profiling, through LC-ESI/LTQOrbitrap/MS Analysis, of Antioxidant Extracts from <i>Physalis alkekengi</i> L.
by: Maria Assunta Crescenzi, et al.
Published: (2023)

HPLC/ESI-MS and NMR Analysis of Chemical Constitutes in Bioactive Extract from the Root Nodule of <i>Vaccinium emarginatum</i>
by: Hsiang-Ming Huang, et al.
Published: (2021)

Taxifolin stability: In silico prediction and in vitro degradation with HPLC-UV/UPLC-ESI-MS monitoring
by: Fernanda Cristina Stenger Moura, et al.
Published: (2021)

Randomized double-blinded pilot clinical study of the antidiabetic activity of Balanites aegyptiaca and UPLC-ESI-MS/MS identification of its metabolites
by: Hend Rashad, et al.
Published: (2017)

Simultaneous determination of fourteen components of Gumiganghwal-tang tablet in human plasma by UPLC-ESI-MS/MS and its application to pharmacokinetic study
by: Seung-Hyun Jeong, et al.
Published: (2021)

UPLC-ESI-MS/MS and HPTLC Method for Quantitative Estimation of Cytotoxic Glycosides and Aglycone in Bioactivity Guided Fractions of Solanum nigrum L.
by: Karishma Chester, et al.
Published: (2017)

HR-LC-ESI-Orbitrap-MS-Based Metabolic Profiling Coupled with Chemometrics for the Discrimination of Different <i>Echinops spinosus</i> Organs and Evaluation of Their Antioxidant Activity
by: Amel Bouzabata, et al.
Published: (2022)

In Vitro Antiviral Effect and Potential Neuroprotection of <i>Salvadora persica</i> L. Stem Bark Extract against Lipopolysaccharides-Induced Neuroinflammation in Mice: LC-ESI-MS/MS Analysis of the Methanol Extract
by: Reem Binsuwaidan, et al.
Published: (2023)

Influence of Accelerated Solvent Extraction Conditions on the LC-ESI-MS/MS Polyphenolic Profile, Triterpenoid Content, and Antioxidant and Anti-lipoxygenase Activity of <i>Rhododendron luteum</i> Sweet Leaves
by: Marta Olech, et al.
Published: (2020)

Qualitative and Quantitative Analysis of Different <i>Rhodiola rosea</i> Rhizome Extracts by UHPLC-DAD-ESI-MS<sup>n</sup>
by: Fabian Alperth, et al.
Published: (2019)

Profile of Phenolic Compounds of <i>Prunus armeniaca</i> L. Leaf Extract Determined by LC-ESI-QTOF-MS/MS and Their Antioxidant, Anti-Diabetic, Anti-Cholinesterase, and Anti-Inflammatory Potency
by: Aneta Wojdyło, et al.
Published: (2021)

HPLC-ESI-qTOF-MS/MS Characterization, Antioxidant Activities and Inhibitory Ability of Digestive Enzymes with Molecular Docking Analysis of Various Parts of Raspberry (<i>Rubus ideaus</i> L.)
by: Lingfeng Wu, et al.
Published: (2019)

Investigation of Algerian <i>Crataegus monogyna Jacq</i> Phenolic Compounds (Using LC-ESI-MS/MS Analysis, Antioxidant Activity, and Enzyme Inhibition) and Their Potential Implications for Food and Nutraceutical Applications
by: Sabrina Goudjil, et al.
Published: (2024)

UPLC-PDA-ESI-QTOF-MS/MS fingerprint of purified flavonoid enriched fraction of Bryophyllum pinnatum; antioxidant properties, anticholinesterase activity and in silico studies
by: Joyce Oloaigbe Ogidigo, et al.
Published: (2021)

Comparative metabolic study of the chloroform fraction of three Cystoseira species based on UPLC/ESI/MS analysis and biological activities
by: Shaza H. Aly, et al.
Published: (2024)

Qualitative and Quantitative Analysis of Phytochemicals in Sayeok-Tang via UPLC-Q-Orbitrap-MS and UPLC-TQ-MS/MS
by: Yu Jin Kim, et al.
Published: (2024)

Characterization of forced degradation products of toloxatone by LC-ESI-MS/MS
by: Robert Skibiński, et al.
Published: (2018)

UHPLC-MS/MS Analysis on Flavonoids Composition in <i>Astragalus membranaceus</i> and Their Antioxidant Activity
by: Zhili Sheng, et al.
Published: (2021)

Profile and Content of Phenolic Compounds in Leaves, Flowers, Roots, and Stalks of <i>Sanguisorba officinalis</i> L. Determined with the LC-DAD-ESI-QTOF-MS/MS Analysis and Their In Vitro Antioxidant, Antidiabetic, Antiproliferative Potency
by: Sabina Lachowicz, et al.
Published: (2020)

Comparative HPLC-DAD-ESI-QTOF/MS/MS Analysis of Bioactive Phenolic Compounds Content in the Methanolic Extracts from Flowering Herbs of <i>Monarda</i> Species and Their Free Radical Scavenging and Antimicrobial Activities
by: Małgorzata Kozyra, et al.
Published: (2023)